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揭开肠道微生物组在心血管疾病中的作用:系统性审查和元分析
Diana Martins1, Cláudia Silva1, António Carlos Ferreira1
1Cardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Biomolecules
|June 27, 2024
概括
人类微生物组对心血管疾病 (CVD) 产生影响,患者中的特定细菌,如链球菌和蛋白质细菌,在患者中增加. 标准化研究方法对于理解这种复杂的关系至关重要.
科学领域:
- 微生物学 微生物学
- 心血管科学 心血管科学
- 代谢学 代谢学 代谢学
背景情况:
- 人类微生物组在心血管疾病 (CVD) 中的作用越来越被认可,但因果关系仍然不清楚.
- 现有研究表明,在健康人和患有心血管疾病的人之间,微生物组成和代谢物之间存在显著的变化.
研究的目的:
- 系统地审查和综合当前关于微生物分类学和CVD中的代谢物变异的知识.
- 识别与心血管疾病相关的特定微生物和代谢特征.
主要方法:
- 2012年至2023年间发表的67项研究的系统审查和元分析.
- 包括来自4707份涵盖各种心血管疾病病理的报告中的元基因组和代谢组数据.
- 分析微生物的α和β多样性,特定的细菌种群和代谢物水平.
主要成果:
- 在健康对照组和心血管疾病患者之间观察到微生物多样性的显著差异.
- 在心血管疾病病例中,Streptococcus和Proteobacteria的丰富性增加,以及Fecalibacterium的减少.
- 高水平的三甲基胺N-氧化物,禁食葡萄糖和甘油三,以及降低胆固醇水平,与心血管疾病有关.
结论:
- 特定的细菌物种和心血管疾病发展之间存在着显著的关系.
- 研究方法和报告标准的重大不一致性阻碍了该领域的进展.
- 研究方法的标准化和全面指导方针的制定对于推进心血管疾病中的微生物组研究至关重要.
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