探索COVID-19入院患者的先前抗生素暴露特征:开放安全
Ya-Ting Yang1, David Wong1,2, Xiaomin Zhong1
1Centre for Health Informatics, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, UK.
广泛使用抗生素,包括多样性和近期使用,与严重的COVID-19结局有关. 需要明智的处方,特别是对于高风险患者,以减轻与反复暴露于抗生素相关的风险.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 之前的研究表明,抗生素使用与严重的COVID-19之间存在相关性.
- 了解COVID-19患者的细节抗生素暴露模式至关重要.
研究的目的:
- 研究特定抗生素暴露特征与严重的COVID-19结果之间的关联.
- 在COVID-19患者中识别与抗生素使用相关的危险因素.
主要方法:
- 在英格兰使用OpenSAFELY平台对316万名COVID-19患者的分析.
- 机器学习模型根据三年抗生素病史将患者分为十个组.
- 与没有住院记录的匹配对照进行比较.
主要成果:
- 与总抗生素处方,类型多样性,广泛使用,处方之间的时间和最近使用相关的严重COVID-19结局的风险增加.
- 暴露在抗生素中最高的患者在严重结局方面调整后的几率比为4.8.
- 在广泛使用抗生素和严重的COVID-19之间发现了显著的联系.
结论:
- 广泛使用抗生素可能会增加严重COVID-19的风险.
- 建议在初级保健中明智地处方抗生素,特别是在易受感染的人群中.
- 强调需要平衡抗生素的益处与潜在的不良影响.
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