对核模糊的自身免疫在长期COVID-19和接种疫苗的受试者中都是可能的:科学证据和工作假设
Silvestro Ennio D'Anna1, Alessandra Maria Vitale2, Giuseppa D'Amico2
1Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
Biology
|June 27, 2024
概括
针对阴道神经蛋白的自身抗体可能导致长期COVID的神经植物性症状. 这些自身抗体在长期COVID患者和接种疫苗的人群中被发现,这表明SARS-CoV-2感染和疫苗接种机制复杂.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 后COVID-19状态 (长COVID) 影响10-20%的个人,通常有神经植物性症状.
- 分子仿真是一种拟议的机制,其中病毒会触发对宿主蛋白质的自身抗体的产生.
- SARS-CoV-2 蛋白质与人类蛋白质共享免疫性,这些蛋白质在阴道核中表达.
研究的目的:
- 为了调查长期COVID患者中对阴道核蛋白质的自身抗体的存在.
- 探索长期COVID中神经植物性症状的潜在自身免疫机制.
- 为了比较长期COVID,接种疫苗和未接种疫苗的个体中自身抗体的存在.
主要方法:
- 对血液样本进行免疫检测测试.
- 对两种特定的核蛋白与SARS-CoV-2尖端糖蛋白共享的自身抗体的分析.
- 包括三组患者:长期COVID症状,接种疫苗 (没有COVID-19病史) 和未接种疫苗 (没有COVID-19病史).
主要成果:
- 在长期COVID患者中检测到假定自身抗体.
- 有趣的是,在没有 SARS-CoV-2 感染史的接种疫苗的人群中也发现了类似的自身抗体.
- 这些自身抗体的存在表明在这两种疾病中都有潜在的自身免疫成分.
结论:
- 对阴道核蛋白的自身抗体可能通过分子模拟对长期COVID中神经植物性症状作出贡献.
- 这些发现引发了关于长期COVID和SARS-CoV-2疫苗接种中共享或独特的致病机制的问题.
- 需要进一步的研究来阐明自身免疫在后病毒综合征和疫苗反应中的作用.
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