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低血糖和反弹高血糖对蛋白质心血管风险生物标志物的影响
Manjula Nandakumar1, Thozhukat Sathyapalan2, Stephen L Atkin1
1Research Department, Royal College of Surgeons in Ireland, Adliya P.O. Box 15503, Bahrain.
低血糖,而不是葡萄糖的波动,增加了心血管风险. 蛋白质生物标志物在低血糖期间发生变化,但在一小时内消失,表明事件本身是危险因素.
科学领域:
- 心血管疾病生物标志物 心血管疾病生物标志物
- 代谢障碍 代谢障碍 代谢障碍
- 蛋白质组学是指蛋白质组学
背景情况:
- 低血糖与心血管事件有关.
- 葡萄糖的变化可能会增加心血管风险.
- 低血糖和随后的高血糖对心血管蛋白质生物标志物的影响尚未完全理解.
研究的目的:
- 为了研究轻度和严重的阳性低血糖症对蛋白质性心血管风险蛋白质标志物的影响.
- 为了比较2型糖尿病 (T2D) 患者和健康对照者的这些影响.
- 评估严重低血糖症后反弹高血糖症的影响.
主要方法:
- 对比了两项阳性低血糖研究:轻度 (n=18) 和严重 (n=46) 与T2D和对照组.
- 使用SOMAscan测定来测量54种心血管蛋白质生物标志物.
- 评估了与炎症,新陈代谢,细胞粘附,免疫反应和补体激活相关的生物标志物.
主要成果:
- 在对照组中,严重的低血糖症增加了angiopoietin 1 (ANGPT1) 和Dickkopf-1 (DKK1),但轻度的低血糖症没有影响任何蛋白质.
- 2型糖尿病患者在轻度和重度低血糖期间都显示出CDO兄弟 (BOC) 的抑制.
- ANGPT1,DKK1和BOC的变化在低血糖症后1小时内消失,在反弹高血糖症期间没有进一步变化.
结论:
- 心血管疾病的蛋白质生物标志物对低血糖反应.
- 这些生物标志物变化是短暂的,在低血糖事件发生后一小时内消失.
- 心血管风险似乎与低血糖本身有关,而不是葡萄糖波动或反弹高血糖症.
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