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近一半的患有无塑性甲状腺癌的患者可能接受免疫治疗
Beverley Chern1, Diluka Pinto1,2, Jeffrey Hy Lum3
1Division of Endocrine Surgery, National University Hospital Health System, Lower Kent Ridge Road, Singapore 119074, Singapore.
Biomedicines
|June 27, 2024
概括
几乎一半的甲状腺癌 (ATC) 患者表达编程细胞死亡联体-1 (PD-L1),这表明他们可能有资格接受免疫治疗. 差异化癌症 (PDC) 患者没有显示PD-L1表达.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 甲状腺癌研究研究
背景情况:
- 差异化癌症 (PDC) 和形甲状腺癌 (ATC) 是一种具有有限治疗策略的侵袭性甲状腺恶性瘤.
- 编程细胞死亡-1 (PD-L1) 表达是一种生物标志物,用于预测各种癌症中对免疫检查点抑制剂治疗的反应.
研究的目的:
- 评估PD-L1表达在患有PDC和ATC的患者.
- 评估这些甲状腺癌亚型在免疫治疗中的潜力.
主要方法:
- 在2000年至2020年期间被诊断患有PDC或ATC的患者的回顾性队列审查.
- 在瘤样本上进行了免疫组织化学 (PD-L1 22C3 pharmDx).
- 瘤比例得分 (TPS) 用于量化PD-L1表达.
主要成果:
- 在19名患者中,15名 (79%) 患有ATC,4名 (21%) 患有PDC.
- 在15名 (47%) 的ATC患者中,在7名患者中检测到PD-L1表达,但在PDC患者中没有.
- PD-L1表达与治疗,疾病阶段,转移或生存没有相关性.
结论:
- 大约47%的形甲状腺癌患者表现出PD-L1表达.
- 这些发现表明,ATC患者的一个子集可能会从免疫疗法中受益,例如 pembrolizumab.
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