相关实验视频

Updated: Jun 22, 2025

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

病毒诱导的微RNA调制和系统性硬化症疾病

Irene Soffritti^1,2, Maria D'Accolti^1,2, Francesca Bini^1,2

¹Section of Microbiology, Department of Chemical, Pharmaceutical and Agricultural Sciences and LTTA, University of Ferrara, 44121 Ferrara, Italy.

|June 27, 2024

概括

微RNAs (miRNAs) 在系统性硬化症 (SSc) 中表现异常,可能作为疾病标志物. 像HCMV/HHV-6这样的病毒感染可能会影响这些miRNA变化,从而导致SSc的发展.

科学领域:

生物化学生化学
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

微RNAs (miRNAs) 是关键的转录后基因调节者,参与许多生理和病理途径.
系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病,其特征包括血管问题,免疫功能障碍和纤维化.
像氧化应激,化学物质和病毒感染 (HCMV,HHV-6) 这样的环境因素都与SSc的发病有关.

研究的目的:

审查SSc患者miRNA变化的当前数据.
探索SSc.中的miRNAs的诊断和预后潜力.
调查潜在的SSc病因因子对miRNA配置文件的影响.

主要方法:

对SSc.中的miRNA表达研究的文献综述.
对将病毒感染 (HCMV,HHV-6) 与SSc.中的miRNA调制联系起来的研究进行分析.
在SSc患者和对照中对miRNA签名的发现的综合分析.

主要成果:

在SSc患者中观察到失调的miRNA表达,无论是细胞内还是细胞外.
病毒感染,特别是HCMV和HHV-6,可以改变miRNA配置文件,模仿SSc模式.
这些病毒诱导的miRNA变化可能会促进SSc相关的病理途径.

结论:

改变的miRNA配置文件代表了SSc疾病的潜在特征.
miRNAs作为SSc.的诊断或预后生物标志物具有前途.
HCMV/HHV-6感染可能会显著影响miRNA调制,从而导致SSc病因.

关键词:

系统性硬化症系统性硬化症贝塔-疹病毒的病毒.生物标志物生物标志物这是一个微型RNA.

更多相关视频

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

Published on: August 10, 2018

MicroRNA-based Regulation of Picornavirus Tropism

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

siRNA - Small Interfering RNAs

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...