功能性内镜鼻手术后西利托尔鼻灌的有效性和安全性:一项随机对照研究
Rong-San Jiang1,2,3, Yi-Fang Chiang4, Kai-Li Liang2,3,4,5
1Departments of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Biomedicines
|June 27, 2024
概括
在功能性内镜鼻手术 (FESS) 后,xylitol鼻灌有效改善了鼻症状,并减少了金黄色葡萄球菌. 这种安全和有益的治疗可以增强康复,没有不良影响.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 利醇表现出抗菌和抗粘性特性.
- 它在功能性内镜外科手术 (FESS) 的术后护理中的作用需要评估.
- 经过FESS的慢性鼻炎患者是增强恢复协议的候选人.
研究的目的:
- 评估在FESS手术后护理中使用西利鼻灌的疗效和安全性.
- 为了比较利醇灌与正常盐水 (NS) 灌.
- 评估对鼻症状,内镜评分,细菌负载和炎症标志物的影响.
主要方法:
- 一项随机对照试验,涉及70名FESS患者.
- 手术后2个月,每天用5%的西利或NS灌鼻子.
- 对鼻腔症状的评估 (鼻腔结局测试),内镜检测结果,嗅觉功能,细菌培养和细胞因子 (交叉蛋白-5,交叉蛋白-17A).
主要成果:
- 利灌显著降低了内镜评分,改善了嗅觉值.
- 观察到黄金葡萄球菌 (Staphylococcus aureus) 流行率显著下降.
- 鼻洗后Xylitol灌中增加了Interleukin-5和Interleukin-17A的水平. 在Xylitol灌后鼻洗中增加了Interleukin-5和Interleukin-17A的水平.
结论:
- 利鼻灌是术后FESS护理的安全和有益的补充.
- 它有效地改善鼻腔结局,并调节鼻腔微生物群.
- 没有报告与西利灌相关的不良事件,包括欧斯塔基管功能.
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