思想理论:对候选基因的简要回顾
Corrado Silvestri1, Simona Scaini1,2, Ludovica Giani1
1Child and Youth Lab, Sigmund Freud University of Milan, Via Ripa di Porta Ticinese 77, 20143 Milan, Italy.
Genes
|June 27, 2024
概括
与心智理论 (ToM) 相关的遗传变异显示出不一致的结果. 这篇评论强调了心理化的复杂遗传基础,需要进一步的研究来澄清基因-ToM关联.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 心理病理学 心理病理学
背景情况:
- 心理理论 (ToM) 的缺陷,即理解他人的心理状态的能力,与精神病理学有关.
- 了解ToM的遗传基础对于解释个体差异和相关疾病至关重要.
研究的目的:
- 系统地审查研究基因多态性及其与儿童和成人心智化表现相关的遗传研究.
- 在思维理论的遗传基础上综合现有证据.
主要方法:
- 按照PRISMA指南进行系统的文献审查.
- 搜索了PubMed和EBSCOhost数据库,使用关键词:"思维理论"",心智化"",小读"",基因"",遗传基础".
- 包括19项检查基因多态和ToM性能的研究.
主要成果:
- 多种基因 (例如DRD4,DAT1,OXTR,COMT) 已被研究出它们在ToM中的作用.
- 结果是有争议的,研究报告了特定基因多态和思维能力之间的关联,而不是相关性.
- 在研究中观察到异质的结果,即使是相同的基因家族和年龄组.
结论:
- 目前的证据不允许对影响ToM.的特定基因多态性产生明确的结论.
- 心理化的遗传基础是复杂的,需要进一步调查.
- 本综述确定了未来对TOM遗传因素的研究的关键基因.
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