化疗的妇产毒性影响和潜在的保护机制
Anna Markowska1, Michał Antoszczak2, Janina Markowska3
1Department of Perinatology and Women's Health, Poznań University of Medical Sciences, 60-535 Poznań, Poland.
Cancers
|June 27, 2024
概括
化疗可能会损害卵巢储备,导致不孕. 本综述探讨了在癌症治疗期间可能保护卵巢功能的激素,天然化合物和合成剂.
科学领域:
- 生殖医学是一种生殖医学.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 化疗,一种主要的癌症治疗,可以导致女性显著的妇产毒性副作用.
- 抑制卵巢储备和雌激素缺乏导致癌症患者的生活质量下降,不孕症和早期更年期.
- 经典的化细胞静止剂是特别有毒的,通过DNA损伤,氧化应激和中断的信号通路损害卵巢卵泡.
研究的目的:
- 审查各种药物的潜在有益作用,以预防化疗诱导的妇科毒性.
- 探索激素,亡路调节剂和天然/合成化合物的有效性,以保护卵巢储备.
主要方法:
- 在化疗期间检查卵巢储备保护的体外试验,动物模型和人体研究的综述.
- 专注于精选的激素 (AMH, ghrelin, LH, melatonin),细胞亡/基因表达调节剂 (C1P, S1P, microRNA) 和天然/合成化合物.
主要成果:
- 鉴定了几种药物,包括荷尔蒙,天然化合物 (quercetin,resveratrol) 和合成药物 (metformin,tamoxifen),具有潜在的保护作用.
- 这些药物向的是卵巢细胞中的DNA损伤,氧化应激和亡等机制.
结论:
- 研究的药物显示出保护和改善接受化疗的癌症患者的卵巢储备的承诺.
- 进一步的精心设计的临床试验至关重要,以确认它在改善荷尔蒙功能和生育能力方面的有效性.
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