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Updated: Jun 22, 2025

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在非小细胞肺癌 (NSCLC) 治疗中使用免疫检查点抑制剂:Quo Vadis?

Antonios N Gargalionis1, Kostas A Papavassiliou2, Athanasios G Papavassiliou3

  • 1Laboratory of Clinical Biochemistry, 'Attikon' University General Hospital, Medical School, National and Kapodistrian University of Athens, Chaidari, 12462 Athens, Greece.

International journal of molecular sciences
|June 27, 2024
PubMed
概括

肺癌是全球主要的健康问题,是第二常见的癌症和癌症相关死亡的主要原因. 了解其流行率对于公共卫生倡议和研究工作至关重要.

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Targeted Cancer Therapies

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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