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叉头盒 P3 T 调节性淋巴细胞的表达作为恶性黑色素瘤的预后因素
Vlad Alexandru Gâta1,2, Andrei Pașca1,2, Andrei Roman2,3
1Department of Surgical Oncology and Gynecologic Oncology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
International journal of molecular sciences
|June 27, 2024
概括
调节性T细胞 (Tregs) 中高叉头盒P3 (FoxP3) 表达表明原发性黑色素瘤患者的预后更差. 阳性FoxP3表明转移,复发和死亡的风险增加,建议将其用作独立的预后因素.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
背景情况:
- 叉头盒P3 (FoxP3) 是调节性T细胞 (Tregs) 的特定标记物.
- 包括黑色素瘤在内的癌症中FoxP3的预后价值仍然有不一致的报道.
- 调节性T细胞在瘤免疫和进展中起着复杂的作用.
研究的目的:
- 评估Treg FoxP3表达在原发性恶性黑色素瘤的预后影响.
- 为了将FoxP3表达与临床病理预后因素相关联.
- 为了确定FoxP3表达是否可以作为黑色素瘤的独立预后标志物.
主要方法:
- 对pT3阶段原发性恶性黑色素瘤患者的回顾性分析.
- 在氨酸嵌入瘤组织上对Treg FoxP3表达的免疫组合化学染色.
- 福克斯P3表达与患者结局和临床病理学数据的相关性.
主要成果:
- 81%的患者表现出正的Treg FoxP3表达.
- 阳性FoxP3表达与淋巴结转移,瘤复发和死亡的风险更高相关.
- 阳性FoxP3表达与较短的整体存活 (OS) 有关.
- 多变量分析确定了积极的FoxP3表达和淋巴结转移作为死亡率的独立预测因素.
结论:
- 特雷格FoxP3表达是原发性恶性黑色素瘤的显著独立预后因素.
- 阳性FoxP3表达表明预后较差,疾病进展风险更高.
- 评估FoxP3表达可能有助于风险分层和管理黑色素瘤患者.
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