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在肝细胞癌中胃类型表达特征

Rita Szodorai^1,2, Laura Banias^1,2, Ilona Kovalszky³

¹Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Targu Mures, Romania.

International journal of molecular sciences

|June 27, 2024

概括

含有V集和免疫球蛋白域1 (VSIG1) 和甲状腺转录因子1 (TTF-1) 的阳性,可以确定一种特定的胃类型肝细胞癌 (HCC). 这种亚型表现出腺体结构,维丁消极性和改善的整体存活率 (OS).

科学领域:

肝细胞癌 (HCC) 研究研究
胃肠道瘤学胃肠道瘤学
生物标志物发现发现

背景情况:

含有V集和免疫球蛋白域1 (VSIG1) 是一种细胞粘附分子,与更好的胃癌存活率有关.
假设VSIG1与甲状腺转录因子1 (TTF-1) 的相互作用定义了胃类型的HCC,但其临床意义尚不清楚.
对VSIG1在上皮介质转换 (EMT) 中的潜在作用,需要对HCC进行研究.

研究的目的:

为了研究VSIG1,TTF-1和Vimentin (VIM) 在HCC中的相互作用.
为了确定VSIG1和TTF-1在HCC中的共同表达的临床意义.
为了验证胃类型HCC的存在和特征.

主要方法:

在217个HCC组织样本上进行了免疫组织化学 (IHC) 染色.
瘤细胞和正常肝细胞被分析为VSIG1,TTF-1和Vimentin (VIM) 的表达.
使用统计分析将标记物表达与临床病理特征和整体存活率 (OS) 相关联.

主要成果:

在52.07%的HCC病例中观察到VSIG1阳性.
同时的VSIG1和TTF-1阳性发生在32.71%的HCC中,与G1/G2癌症,状骨架构和较长的OS相关 (p = 0.004).
在VSIG1/TTF-1和Vimentin (VIM) 表达之间发现了显著的负相关性 (p < 0.0001). 斯基罗型HCC对所有标志物是负的.

结论:

这项研究证实了胃类型HCC的存在,其特点是腺状结构.
这种胃类型的HCC是由VSIG1和TTF-1共阳性,Vimentin阴性和显著更长的整体存活率来定义的.
VSIG1和TTF-1作为潜在的生物标志物用于识别一个独特的,预后有利的HCC亚型.

关键词:

在TTF-1中.在VSIG1中,VSIG1是VSIG1.表皮 mesenchymal 过渡的转变.胃类型胃类型肝细胞癌是肝细胞癌.在这里,你会看到Vimentin.

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