马特林通过抑制炎症,调节氧化应激和重塑肠道微生物群来改善DSS诱导的大肠炎
Ningning Mao1,2, Yaming Yu1,2, Jin He1,2
1Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
International journal of molecular sciences
|June 27, 2024
概括
马特林 (MT) 通过改善肠道屏障功能,平衡免疫细胞和恢复肠道微生物群,有效治疗小鼠的性结肠炎 (UC). 这种天然化合物显示出作为UC的饮食疗法的前景.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 马特林 (MT) 具有抗炎,抗过敏和抗氧化特性.
- 马特林对大肠炎的影响的确切机制在很大程度上仍未被阐明.
- 性结肠炎 (UC) 是一种慢性炎症性肠病,具有显著的未满足治疗需求.
研究的目的:
- 在小鼠模型中研究马林对硫酸 (DSS) 诱导的性结肠炎的保护作用.
- 阐明母蛋白在结肠炎中发挥治疗作用的潜在机制.
主要方法:
- 在小鼠中诱导大肠炎使用硫酸 (DSS).
- 将母体 (MT) 给DSS治疗的小鼠.
- 评估临床症状,结肠组织学,肠道屏障标记物 (ZO-1,奥克卢丁),氧化应激,炎症性细胞因子,T细胞群 (Treg/Th17) 和肠道微生物群组成.
主要成果:
- 马特林显著缓解了DSS诱导的大肠炎症状,包括体重减轻,结肠缩短和疾病活动指数.
- MT逆转了肠道损伤,恢复了杯状细胞数量,并改善了紧结蛋白 (ZO-1,occludin) 的表达.
- 马特林减少了氧化应激和炎症性细胞因子的产生,重新平衡了Treg/Th17细胞,并调节了肠道微生物群的多样性和组成,有利于像Lactobacillus和Akkermansia这样的有益细菌.
结论:
- 马特林通过增强结肠壁的完整性,重新平衡Treg/Th17细胞,抑制炎症和调节氧化应激来缓解DSS诱导的大肠炎.
- 孕对肠道微生物群的组成和大肠炎模型中的多样性产生积极影响.
- 这些发现支持马林作为性结肠炎的饮食治疗剂的潜力.
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