预测第一个情节精神病中的大脑年龄:与缺乏表现力的关联
Dean F Salisbury1, Brian M Wulf1, Dylan Seebold1
1Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Brain sciences
|June 27, 2024
概括
精神分裂症患者在第一次发作时不会表现出加速的大脑衰老. 然而,年轻的预测大脑年龄与更好的词汇相关,而年长的预测大脑年龄与精神分裂症的负面症状有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 加速的大脑衰老是精神分裂症病理学的潜在因素.
- 使用MRI的大脑发育算法可以估计一个人的预测大脑年龄 (PBA).
研究的目的:
- 与健康对照组 (HC) 相比,研究PBA在第一发精神分裂症 (FESz) 中.
- 为了确定PBA是否与神经认知,社会功能或FESz.症状严重程度有关.
- 为了探索PBA中的性别差异.
主要方法:
- 使用BrainAgeR (v2.1) 从T1加权MRI扫描中计算PBA.
- 在70 FESz和76 HC之间比较PBA.
- 分析了PBA与神经认知,社会和症状指标之间的关联,对时间年龄进行控制.
主要成果:
- 在FESz和HC组之间没有PBA的显著差异.
- 年轻的PBA与所有参与者的词汇分数更高相关.
- 在FESz.中,较旧的PBA与更严重的"缺乏表现力"负面症状有关.
- 与两组男性相比,女性参与者表现出较高的PBA.
结论:
- 没有证据表明在青春晚期/成年早期出现第一次精神分裂症时,大脑衰老加速.
- 更年轻的预测大脑年龄与更好的语义记忆有关.
- 具有较高残留PBA的FESz显示出特定的负面症状损伤,表明潜在的与年龄有关的病理.
- 观察到PBA的性别差异,女性PBA升高.
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