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在后COVID-19条件和COVID-19康复期个体中对淋巴细胞群体的比较分析

Luisa Berger¹, Johannes Wolf^2,3, Sven Kalbitz¹

¹Department of Infectious Diseases and Tropical Medicine, Hospital St. Georg, 04129 Leipzig, Germany.

Diagnostics (Basel, Switzerland)

|June 27, 2024

概括

长期COVID可能不会导致持久的免疫细胞变化. 虽然COVID-19患者显示B细胞和T辅助细胞减少,但COVID-19后病情 (PCC) 患者与对照人群相比没有表现出独特的长期免疫异常.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
血液学血液学血液学

背景情况:

病毒感染通常会在急性阶段减少淋巴细胞数量.
SARS-CoV-2 感染的长期免疫后果,特别是在后COVID-19 条件 (PCC) 中,仍然不清楚.
病毒感染后持续的细胞变化表明PCC中可能存在类似的异常.

研究的目的:

为了研究COVID-19患者适应性免疫系统的长期细胞变化.
为了比较PCC和没有PCC的患者中的淋巴细胞亚种群与健康对照.
为了确定PCC是否与特定的,持久的免疫细胞异常有关.

主要方法:

从淋巴细胞亚种群的流动细胞计数据的回顾性分析.
包括106名确诊的SARS-CoV-2患者和28名未暴露的健康对照 (UHC).
患者被分为三个随访组;COVID-19患者,PCC患者和UHC之间的比较.

主要成果:

与UHC相比,在COVID-19患者的最后一次随访中观察到IgA+CD27+,IgG+CD27+,IgM+CD27-和切换B细胞的显著减少.
与UHC相比,T辅助细胞和类切换B细胞在PCC和COVID-19康复群体中显示出显著的差异.
与非PCCCOVID-19患者相比,在PCC患者中没有检测到任何特定或长期的免疫细胞变化.

结论:

COVID-19 感染与减少的 B 淋巴细胞子集和改变的 T 辅助细胞有关,即使是在后期阶段.
与其他COVID-19康复者相比,后COVID-19状态 (PCC) 似乎没有明显的,持久的免疫细胞异常.
可能需要进一步的研究,以充分阐明SARS-CoV-2感染和PCC的长期免疫影响.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.免疫系统免疫系统长时间的COVID.淋巴细胞亚种群的淋巴细胞亚种群.后COVID-19情况 (PCC)后急性COVID综合征的发生.

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