研究有毒金属和肝脏疾病中必需元素的相互作用
Aderonke Gbemi Adetunji1,2, Emmanuel Obeng-Gyasi1,2
1Department of Built Environment, North Carolina A&T State University, Greensboro, NC 27411, USA.
概括
暴露于会显著增加肝病和非酒精性脂肪性肝病 (NAFLD) 的风险,特别是当与其他有毒金属和基本元素相结合时. 这项研究突出显示了的含量.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 肝脏疾病,包括非酒精性脂肪性肝病 (NAFLD),代表着全球健康的重大负担.
- 对有毒金属的环境暴露和基本元素的不平衡与肝脏疾病的发病有关.
- 了解这些元素之间的复杂相互作用对于评估肝病风险至关重要.
研究的目的:
- 研究有毒金属 (,,) 和基本元素 (,) 对肝病风险的单独和联合影响.
- 评估这些因素对肝损伤生物标志物和非酒精性脂肪性肝病 (NAFLD) 风险的影响.
- 通过先进的统计建模,阐明有毒金属和基本元素在肝病病因学中的作用.
主要方法:
- 利用了来自国家健康和营养检查调查 (2017-2018) 的数据.
- 使用描述性统计学,线性回归和贝叶斯内核机器回归 (BKMR) 进行单变量,双变量和整体效应分析.
- 评估了暴露-反应函数,相互作用,并计算了后续包含概率 (PIPs) 来确定元素的重要性.
主要成果:
- (Pb) 在导致肝病方面表现最为重要 (PIP = 1.000),其次是 (Hg) (PIP = 0.9512).
- 暴露与NAFLD风险和肝损伤生物标志物 (ALT,AST,ALP,GT,总 bilirubin) 有显著的积极关联.
- 与其他金属和基本元素对Pb的联合暴露显示出积极的毒性趋势和从第60至第75百分点增加的NAFLD风险.
结论:
- 暴露是导致肝病发展的重要因素,特别是在与其他环境污染物和基本元素相互作用时.
- 有毒金属和基本元素的联合作用对包括NAFLD在内的不良肝脏结果构成相当大的风险.
- 公共卫生战略应考虑环境暴露对肝脏健康的累积影响.
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