男人微量营养素抗氧化剂 (Menevit®) 通过减少氧化应激来改善精子功能,从而改善辅助生殖技术的结果
Seiji Ogawa1,2, Kuniaki Ota3,4, Kaori Nishizawa1
1Sendai ART Clinic, 206-13 Nagakecho, Miyagino, Sendai 983-0864, Miyagi, Japan.
Antioxidants (Basel, Switzerland)
|June 27, 2024
概括
微量营养素抗氧化剂,包括叶酸和,可以改善精子质量,减少接受生育治疗的男性的氧化应激. 这种干预也导致了接受辅助生殖技术的夫妇的临床怀孕率增加.
科学领域:
- 生殖医学 生殖医学
- 男人的健康 男人的健康
- 氧化压力研究研究 氧化压力研究
背景情况:
- 氧化应激 (OS) 对男性生育能力和精子生产产生负面影响.
- 抗氧化剂补充剂对男性不孕症的有效性尚未得到充分证实.
- 辅助生殖技术 (ART) 的结果可能受到男性因子不孕症的影响.
研究的目的:
- 评估每日微量营养素抗氧化剂对精子氧化应激的影响.
- 为了确定抗氧化剂补充是否改善精液参数和质量.
- 评估抗氧化剂对ART植入和怀孕率的影响.
主要方法:
- 一项为期6个月的随机对照试验,涉及171名接受ART的夫妇的男性伴侣.
- 参与者每天接受抗氧化剂 (叶酸和) 或安慰剂.
- 在3个月和6个月时分析血清氧化剂水平,精子参数,骨质系统和DNA碎片化.
- 胚胎移植后的植入,临床怀孕和流产率的比较.
主要成果:
- 在具有高基线sORP的男性中,观察到精子度和静态氧化降低潜力 (sORP) 的显著改善.
- 发现了向高质量的胚胎囊率增加的趋势.
- 植入和临床怀孕率在6个月的抗氧化剂补充后显著增加.
结论:
- 微量营养素抗氧化剂可以有效地减少精子氧化应激,并增强精子功能.
- 抗氧化剂补充剂显示出作为男性不孕症可行的治疗方法的承诺.
- 通过抗氧化剂改善精子质量,积极影响ART成功率.
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