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透技术在脏异构移植的保存,以减少缺血性再输液损伤:一个系统的审查和元分析

Bima J Hasjim¹, Jes M Sanders², Michael Alexander¹

¹Department of Surgery, Division of Hepatobiliary and Pancreas Surgery and Islet Cell Transplantation, University of California-Irvine, Orange, CA 92868, USA.

Antioxidants (Basel, Switzerland)

|June 27, 2024

概括

机器输液 (MP) 和正常热区域输液 (NRP) 通过减少移植失败和急性排斥来改善移植结果. 这些先进的保存方法有助于扩大捐赠者池,使脏移植更加成功.

科学领域:

科和移植手术移植手术
器官保存和 perfusion 技术器官保存和 perfusion 技术器官保存和 perfusion 技术器官保存和 perfusion 技术器官保存和 perfusion 技术器官保存和 perfusion 技术

背景情况:

由于对移植的需求日益增加,需要使用易受缺血再输液损伤 (IRI) 的异构移植.
先进的器官保存技术,如机器输液 (MP) 和常温区域输液 (NRP),旨在减轻IRI并保持全移植功能.

研究的目的:

与传统脏保存方法相比,系统地审查和元分析MP和NRP的好处.
评估MP和NRP对移植失败,术后结果和急性排斥率的影响.

主要方法:

通过PubMed,Embase,Cochrane和Scopus识别的研究的系统审查和元分析.
包括54个手稿 (41个MP,13个NRP),将MP和NRP与静态冷藏或现场输液进行比较.

主要成果:

机器输液 (MP) 显著降低了12个月的移植失败 (OR 0.67) 和改善了外科手术后的结果,包括减少延迟的移植功能 (OR 0.65) 和初级非功能 (OR 0.63).
此外,MP还导致住院时间缩短 (15.5天而不是18.4天).
与现场输液相比,常温区域输液 (NRP) 降低了急性排斥率 (OR 0.48).

结论:

MP和NRP是有效的缓解缺血再输伤害 (IRI) 在移植.
这些先进的输液技术在安全地扩大捐赠者池中发挥着至关重要的作用,以满足对移植的日益增长的需求.

关键词:

抗氧化剂抗氧化剂是一种抗氧化剂.在现场冷保存.缺血性再注射损伤的伤害机器 perfusion perfusion perfusion 透机是什么? 机器是什么? 机器是什么?常温区域 perfusion 区域 perfusion 是一个常温区域 perfusion 系统.器官的保存器官的保存静态冷藏库的冷藏库是什么

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