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职业接触金属基纳米材料:化学成分和氧化应激生物标志物之间的可能关系

Valeria Bellisario¹, Giacomo Garzaro¹, Giulia Squillacioti¹

¹Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy.

Antioxidants (Basel, Switzerland)

|June 27, 2024

概括

尿中的金属度,如二氧化 (Si) 和 (Ti),可以可靠地生物监测对纳米材料 (NM) 的职业暴露. 这项研究强调了NMS作为一个被低估的工作场所危险,影响氧化平衡.

科学领域:

职业健康职业健康职业健康
环境科学环境科学
毒理学毒理学毒理学

背景情况:

纳米材料 (NM) 提供了多样化的应用,但由于工作场所暴露的人类健康数据有限,它们带来了毒性挑战.
对MN暴露的生物监测对于了解职业健康风险至关重要.
尿中的金属度被探索为NM暴露的潜在生物标志物.

研究的目的:

评估尿液金属度的可靠性和实用性,用于生物监测NM暴露.
调查 NM 暴露,尿液中的金属水平和工人的氧化应激 (OS) 生物标志物之间的关联.
评估特定金属,如二氧化 (Si) 在介导NM毒性的作用.

主要方法:

在"纳米探索项目"中招募了43名未暴露的受试者和40名暴露的工人.
测量了特定的NM (PCN,LDSA) 和生物标记物 (尿中的Al,Si,Ti,Cr;OS生物标记物TAP,Isop,MDA) 的工作场所暴露.
利用统计分析,包括调解分析,来解释生物标志物数据.

主要成果:

尿液中的二氧化 (Si) 和 (Ti) 含量与NM暴露 (PCN,LDSA) 和OS生物标志物直接相关,特别是在暴露的工人中.
调解分析表明,Si约占LDSA和OS生物标志物之间的关系的2.8%.
职业接触NM混合物会增加身体的负担,并破坏氧化平衡.

结论:

尿中的金属度,特别是Si和Ti,作为NM暴露的有效生物标志物.
职业接触MN混合物具有低估的健康危害,有助于增加氧化应激.
为了保护工人,需要对NM毒性和生物监测策略进行进一步的研究.

关键词:

进行NM生物监测.NM职业暴露NM职业暴露抗氧化剂防御抗氧化剂防御身体负担是身体负担.纳米尺寸的金属.职业空气污染暴露的情况氧化失衡是一种氧化失衡.

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