在代谢功能障碍相关的肥胖性肝病和肝纤维化中肝细胞线
Jiaxin Chen1,2, Linge Jian1,2, Yangkun Guo1,2
1Laboratory of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu 610041, China.
Antioxidants (Basel, Switzerland)
|June 27, 2024
概括
线粒细胞,即清除受损线粒体的过程,对于代谢功能障碍相关的脂肪性肝病 (MASLD) 和肝纤维化至关重要. 向线粒菌为这些普遍的肝病提供了潜在的治疗策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 细胞生物学 细胞生物学
- 线粒体生物学 线粒体生物学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球三分之一的人口,导致肝衰竭.
- 线粒体功能障碍越来越被认为是MASLD和肝纤维化发展的关键因素.
- 线粒体,一个细胞去除受损线粒体的过程,在肝脏健康中起着至关重要的作用.
研究的目的:
- 阐明在MASLD和肝纤维化中肝细胞菌的机制.
- 探索细胞在各种肝细胞类型中的作用,包括肝细胞,巨细胞,肝星细胞和肝脏侧侧内皮细胞.
- 总结目前和潜在的治疗策略,以向肝细胞衰变为目标.
主要方法:
- 文献综述和现有关于肝脏疾病中线粒细胞衰变的研究的综合.
- 分析不同肝细胞群体中基因细胞衰变的分子机制.
- 鉴定和分类与菌相关的治疗化合物和策略.
主要成果:
- 线粒体功能障碍是MASLD和肝纤维化病原体的重要贡献者.
- 线性对于维持肝细胞功能和预防多种细胞类型的疾病进展至关重要.
- 在临床前研究中,几种针对线粒的治疗药物和策略在临床前研究中显示出有前途.
结论:
- 肝细胞菌是MASLD和肝纤维化发展和进展的关键过程.
- 向线粒菌为治疗MASLD和肝纤维化提供了一个有希望的治疗途径.
- 对线粒细胞调节疗法的进一步研究可能会导致肝脏疾病的临床突破.
关键词:
库弗弗细胞 (KCs) 是一种肝脏星状细胞 (HSCs) 是什么?肝细胞 肝细胞 肝细胞肝脏纤维化 肝脏纤维化肝脏内侧侧状内皮细胞 (LSECs) 是一种肝脏内侧状内皮细胞.巨细胞是什么?巨细胞是什么?与代谢功能障碍相关的脂肪肝炎 (MASH)与代谢功能障碍相关的脂肪性肝病 (MASLD)线粒体中的线粒体.线粒细胞衰变 (mitophagy) 是一种神经衰变的过程.更多相关视频
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
858
09:13Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima
Published on: August 12, 2018
14.8K
相关概念视频
Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
Autophagy
4.2K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.2K
Lysosomal Hydrolases
3.8K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.8K
Delivery Pathways to the Lysosome
6.2K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
6.2K
Liver Physiology
502
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
502
Liver Histology
705
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
705
