心脏热素I升高作为住院COVID-19患者的死亡率预测因子
Ieva Kubiliute1, Jurgita Urboniene2, Fausta Majauskaite1
1Clinic of Infectious Diseases and Dermatovenerology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.
住院COVID-19患者心脏托罗邦素I水平升高表明心肌损伤,预测住院死亡率较高. 这种生物标志物有助于识别高风险个体,以定制治疗策略.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 生物标志物 生物标志物
背景情况:
- COVID-19 影响多个器官系统,尤其是心血管系统.
- 急性心肌损伤是COVID-19患者常见的早期心脏并发症.
- 心脏素I (cTnI) 是心肌损伤的关键指标.
研究的目的:
- 评估心脏托罗邦素I (cTnI) 水平的预后意义.
- 预测COVID-19住院患者的住院死亡率.
主要方法:
- 2019年住院COVID-19患者的回顾性观察队列研究.
- 根据摄入的cTnI水平进行分层:<19 ng/L,19-100 ng/L,和>100 ng/L.
- 使用后勤和考克斯比例危险回归的统计分析.
主要成果:
- 29.87%的患者经历了急性心肌损伤,与并发症有关.
- 升高的cTnI水平显著增加了需要机械通风的可能性.
- 较高的cTnI水平与2.58至2.97倍增加的住院死亡危险比率相关.
结论:
- 住院时cTnI增加意味着COVID-19中心肌损伤.
- 这种生物标志物与更糟糕的临床过程和增加的死亡风险有关.
- cTnI对于识别高风险的COVID-19患者和指导管理非常有价值.
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