在活性类风湿性关节炎中补充西利玛林:试点随机对照临床研究的结果
Georgeta Stefanovici Zugravu1,2, Carmen Pintilescu3, Carmen-Marinela Cumpat2,4
1Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy, 16, Universitatii Street, 700115 Iasi, Romania.
Medicina (Kaunas, Lithuania)
|June 27, 2024
概括
补充西利马林显著改善了类风湿性关节炎症状和患者的幸福感. 这种天然产品增强了常规疾病修饰性抗风湿性药物治疗,提供了有益的辅助治疗.
科学领域:
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
- 营养科学 营养科学
背景情况:
- 自然产品与常规抗风湿治疗的同时使用具有显著的兴趣.
- 作为一种营养补充剂的西利马林被研究其增强常规类风湿性关节炎治疗疗法的功效.
研究的目的:
- 评估西利马林补充剂对接受常规疾病修饰性抗风湿药物 (DMARD) 治疗的活性类风湿性关节炎患者的影响.
- 评估西利马林对疾病活动,炎症标志物和患者报告结果的影响.
主要方法:
- 一项随机对照试验涉及122名患有活跃类风湿性关节炎的患者,这些患者接受了常规DMARD治疗.
- 患者被分配到对照组或干预组,接受西利马林 (300毫克/天) 8周.
- 疾病活动,炎症标志物,残疾指数和心理评分在基线和第8周被测量.
主要成果:
- 补充西利马林导致关节疼痛,胀,早晨硬和疼痛严重程度显著减少.
- 疾病活动和残疾指数,欧洲反风湿联盟 (EULAR) 的反应以及疲劳,抑郁和焦虑的得分有所改善.
- 西利马林显著改善了类风湿性关节炎患者的整体状况.
结论:
- 当用于作为常规DMARDs的活跃类风湿性关节炎患者的辅助治疗时,西利马林补充剂显示出显著的益处.
- 这些发现提供了支持使用西利玛林来改善临床结果和减少类风湿性关节炎疾病负担的证据.
相关概念视频
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
156
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
156
01:29Drugs for Treatment of Ulcerative Colitis in IBD
134
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
134
01:27Combined Effects of Drugs: Synergism
3.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.8K
01:20The JAK-STAT Signaling Pathway
8.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.8K