氧化压力相关的男性不孕症:当前的诊断和治疗方法
Haritha Pavuluri1, Zahra Bakhtiary1, Manesh Kumar Panner Selvam1
1Department of Urology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Medicina (Kaunas, Lithuania)
|June 27, 2024
概括
氧化应激 (OS) 通过破坏精子功能并导致DNA损伤,显著影响男性不孕. 早期诊断和有针对性的治疗,包括抗氧化剂和生活方式改变,可以改善生育结果.
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 生物化学 生物化学
背景情况:
- 男性不孕症影响全球成年人口的很大一部分,男性因素导致20-30%的病例.
- 氧化应激 (OS),反应性氧物种 (ROS) 和抗氧化剂之间的不平衡,是男性不孕症的关键因素.
- OS对精子功能,活力和DNA完整性产生负面影响,阻碍了受精的潜力.
研究的目的:
- 审查氧化应激在男性不孕症中的作用.
- 讨论用于评估OS标记物和抗氧化剂水平在男性不孕症的诊断工具.
- 探索与OS相关的男性不孕症的当前和新兴治疗策略.
主要方法:
- 关于氧化应激和男性不孕不育现有文献的综述.
- 对OS标记物,抗氧化剂水平和细胞内ROS的诊断方法的分析.
- 探索治疗干预措施,包括经验药物,抗氧化剂,纳米抗氧化剂和生活方式改变.
主要成果:
- 氧化应激会诱导精子中的分子变化,包括DNA损伤和脂质过氧化,损害生育能力.
- 诊断工具可以有效地评估OS参数,帮助精确诊断男性不孕症.
- 不同的治疗方法,从抗氧化剂到生活方式的改变,显示在管理OS相关的男性不孕症的潜力.
结论:
- 准确评估OS标志物和抗氧化剂状态对于诊断男性不孕症至关重要.
- 针对OS的有针对性的干预措施可以优化治疗结果并提高受孕率.
- 结合诊断和定制治疗的综合方法对于管理OS相关的男性不孕症至关重要.
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