评分系统的发展概念:从风险估计中减去胆固醇:健康长寿的途径?
Francesco Natale1, Rosa Franzese1,2, Luigi Marotta1,2
1Vanvitelli Cardiology Unit, Monaldi Hospital, 80131 Naples, Italy.
高低密度脂蛋白胆固醇 (LDL-C) 是动脉样硬化心血管疾病 (ASCVD) 的已被证明的原因. 目前的指导方针提倡早期风险分层,并迅速降低LDL-C,以预防重大心血管事件.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 脂质代谢 脂质代谢是什么
背景情况:
- 低密度脂蛋白胆固醇 (LDL-C) 是动脉样硬化心血管疾病 (ASCVD) 的一个成熟的因果风险因素.
- 国际指南建议早期风险分层和积极的LDL-C目标实现,以尽量减少心血管事件.
- 长时间暴露于升高的LDL-C有助于动脉样硬化斑块的发展和进展.
研究的目的:
- 审查支持LDL-C在ASCVD中的因果作用的证据.
- 评估是否有必要将LDL-C纳入风险评估得分.
主要方法:
- 审查当前的科学文献和临床指导方针.
- 分析证据,将LDL-C水平与ASCVD发展和进展联系起来.
- 讨论传统和非传统风险因素与LDL-C相关的作用.
主要成果:
- 确定的LDL-C和ASCVD之间的因果关系.
- 鉴定导致动脉样硬化病变不稳定和血栓形成的因素.
- 强调长期,不受控制的LDL高胆固醇血症的临床意义.
结论:
- 在ASCVD中LDL-C的因果作用是科学接受的.
- 临床实践应采用"走更低,开始更早,保持更长时间"的原则来管理LDL-C.
- 在风险评分中重新评估LDL-C的含有是有必要的.
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