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Wibke Müller-Seubert¹, Lena Fuchs¹, Raymund E Horch¹

¹Laboratory for Tissue Engineering and Regenerative Medicine, Department of Plastic and Hand Surgery, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuernberg (FAU), Krankenhausstr. 12, 91054 Erlangen, Germany.

Journal of personalized medicine

|June 27, 2024

概括

干细胞治疗,包括脂肪衍生干细胞 (ASC) 和介质干细胞 (MSC),通过减少炎症和预防重建性手术中的组织缩,有望改善辐射后的片存活率.

科学领域:

再生医学是一种再生医学.
组织工程是组织工程.
手术瘤学手术瘤学

背景情况:

在重建性外科手术中,局部片有死亡的风险,特别是在瘤治疗的辐射后.
干细胞应用是增强膜 perfusion 和生存的潜在策略.

研究的目的:

调查不同类型的干细胞在改善被辐射的随机模式皮膜片在老鼠生存的疗效.
评估干细胞治疗的抗炎和组织保护作用.

主要方法:

老鼠接受了双边皮带膜手术,其中一个膜被照射 (20 Gy),另一个作为对照.
四种干细胞混合物 (ASCs,ASC-HUVECs,MSCs,MSC-HUVECs) 用纤维素粘合剂在片下被应用.
分析了膜缩,大小和分子标记物 (CD68,ERG,互白素6,HIF-1α,VEGF).

主要成果:

干细胞应用 (ASC,ASC-HUVEC,MSC) 减少了CD68+炎症细胞.
在ASC组中,HIF-1α表达升高.
中细胞干细胞 (MSCs) 和MSC-HUVECs 防止了膜收缩.

结论:

ASC,MSC和ASC-HUVEC显示出抗炎作用.
MSC和MSC-HUVEC有效地预防了早期的片收缩,这表明在重建性手术中具有治疗潜力.

关键词:

在ASC中,ASC是ASC.在HUVECEC中使用.在MSC中,MSC是MSC.辐射辐射辐射的辐射.随机模式的片会出现.

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