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血管病变增加了社区居住的老年人心血管风险,他们患有左心室缩
Rusitanmujiang Maimaitiaili1, Song Zhao1, Jiadela Teliewubai1
1Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai 200072, China.
Journal of personalized medicine
|June 27, 2024
概括
左心室缩 (LVH) 在老年人中显著增加心血管风险,特别是在与多种血管病变相结合时. 衰老也是主要心血管不良事件 (MACE) 的独立风险因素.
科学领域:
- 心脏病学 心脏病学
- 老年学是一门学科.
- 血管医学 血管医学
背景情况:
- 左心室缩 (LVH) 是老年人常见的心脏适应.
- 需要进一步调查LVH,各种血管病变和心血管风险之间的相互作用.
研究的目的:
- 评估不同左心室 (LV) 几何和血管病变在老年人队列中对主要心血管不良事件 (MACE) 的综合影响.
- 在老年人中确定MACE的独立风险因素.
主要方法:
- 对3339名老年人的前性队列研究 (北上海研究).
- 使用心声学对LV几何的分类为正常,集中重塑,偏心缩和集中缩.
- 血管病的分类为动脉样硬化,动脉样硬化和衰老.
- 随访时间中位数为5.7年,以确定MACE (心肌梗塞,中风,心血管死亡).
- 使用考克斯回归和卡普兰-梅尔生存分析的统计分析.
主要成果:
- 集中性缩与更高的高血压患病率,血管硬度增加和最高的MACE率有关.
- 异常缩 (HR: 1.638) 和同心缩 (HR: 1.751) 显著增加了MACE的风险.
- 衰老独立地增加了MACE风险 (HR: 1.361).
- 同时的LVH和多重血管病导致生存概率的最显著降低.
- 在患有高血压,糖尿病或血管疾病的老年男性中,LVH扩大了MACE风险.
结论:
- LVH是老年人心血管不良结果的关键预测因子.
- 多种血管病变的存在增加了LVH患者心血管风险.
- 衰老成为MACEs的一个独特的,独立的风险因素,需要临床关注.
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