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Updated: Jun 19, 2026

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一个患有早期结肠直肠癌和治疗诱导的焦点结节性增生症的患者的基因组和转录组分析:一个病例报告

Mary O'Reilly1,2, Aleksandar Krstic1, Luis F Iglesias-Martinez1

  • 1Systems Biology Ireland, School of Medicine, University College Dublin, D04 V1W8 Dublin, Ireland.

Journal of personalized medicine
|June 27, 2024
PubMed
概括

一名年轻女性的早期结直肠癌 (EOCRC) 被诊断为复杂的遗传特征,包括影响WRN基因的8号染色体缺失. 这种情况表明,化疗的预后和反应是有利的,需要个性化监测.

关键词:
有RAS突变的癌症.维尔纳综合征 (WRN) 类似于维尔纳综合征的酸酶 (WRN)大肠直肠癌 (CRC) 是一种癌症.早期发作的结直肠癌 (EOCRC)焦点结节性过度增生

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Tumor Progression02:07

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...