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在差差分化甲状腺癌 (PDTC) 个性化向治疗的漫长旅程:病例报告和系统审查

Odysseas Violetis¹, Panagiota Konstantakou¹, Ariadni Spyroglou¹

¹2nd Department of Surgery, Aretaieio Athens Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Journal of personalized medicine

|June 27, 2024

概括

差差分化的甲状腺癌 (PDTC) 是具有侵略性的. 当手术失败时,针对性疗法对BRAF突变的,抗放射性的PDTC有希望,为高级病例提供希望.

科学领域:

在瘤学瘤学.
内分泌学在内分泌学.

背景情况:

差差分化的甲状腺癌 (PDTC) 呈现出差差分化的甲状腺癌 (TC) 和形性甲状腺癌之间的中间预后.
PDTC的特点是具有攻击性特征,并且可以抵抗放射性 (RAI) 等标准治疗.

研究的目的:

报告一个具有BRAFV600E突变和放射性耐药性的高级PDTC病例.
系统地审查有关临床病理学特征,分子标记物和PDTC组件的非anaplasticTC管理的文献.

主要方法:

一个45岁的男性病例呈现了PDTC,Hobnail和高细胞变体以及BRAFV600E突变.
使用PubMed,Scopus和Web of Science进行了系统的文献审查,包括82项研究.
该患者接受了多种治疗,包括手术,RAI,向治疗 (伦瓦提尼布,索拉费尼布,达布拉费尼布/特拉美提尼布,卡博赞提尼布) 和放射治疗.

主要成果:

患者在初始治疗后出现了早期复发,并表现出放射性耐药性.
各种分子向治疗提供了暂时的瘤控制.
系统审查确定了PDTC的关键临床病理特征和管理策略.

结论:

结合分子向治疗可能对抗放射性,BRAF突变的先进PDTC.安全有效.
这些疗法提供了潜在的治疗途径,当手术和RAI等传统治疗方法不足时.
需要进一步的研究来优化对这种具有挑战性的甲状腺癌亚型的治疗策略.

关键词:

甲甲状腺癌是什么?在甲状腺癌的分子向疗法.差差分化的甲状腺癌癌.高细胞甲状腺癌高细胞甲状腺癌.

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