微RNAs的表达及其在重复性妊娠损失中的参与
Maria-Markella Patronia1, Anastasios Potiris2, Despoina Mavrogianni1
1First Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Journal of clinical medicine
|June 27, 2024
概括
经常性流产或RPL与改变的microRNA (miRNA) 水平有关. 像miR-100-5p和let-7c这样的特定循环miRNA显示出作为诊断和预后的非侵入性生物标志物的希望.
科学领域:
- 生殖生物学 生殖生物学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 复发性流产 (RPL) 影响24周妊娠前的2个或更多的怀孕.
- 在近一半的病例中,异形性RPL的原因仍然未知,缺乏可靠的诊断工具.
- 微RNAs (miRNAs) 在生殖病理中表现不同.
研究的目的:
- 审查微RNA与异常性反复流产之间的关系.
- 为了将miRNA表达模式与反复流产相关联.
- 评估miRNAs作为诊断和预后生物标记物的潜力.
主要方法:
- 在Pubmed/Medline和Scopus数据库的系统文献搜索,截至2024年1月31日.
- 包括研究微RNA和重复妊娠流产的研究.
- 对已识别的miRNA及其表达模式的分析.
主要成果:
- 包括21项研究,确定了75个差异表达的miRNAs.
- 大约有40个miRNAs表达的增加 (例如,miR-520,miR-184,miR-100-5p).
- 21个miRNA显示表达减少 (例如,let-7c),14个显示变量表达 (例如,miR-21).
结论:
- 微RNA失调与经常性流产密切相关.
- 在外周血液中循环的miR-100-5p和let-7c是潜在的非侵入性生物标志物.
- 这些miRNAs可能为RPL预后和诊断提供一个有价值的未来工具.
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