在一般人群中估计的脉冲波速度和全因和心血管死亡率
Vladimir Prelević1,2, Luka Blagus3, Vito Bošnjak4
1Department of Nephrology, Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, 10000 Zagreb, Croatia.
Journal of clinical medicine
|June 27, 2024
概括
估计的脉冲波速度 (ePWV) 可以预测一般人群的心血管死亡率. 较高的ePWV值与心血管死亡风险增加有关,特别是在心血管风险较高的人群中.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 公共卫生 公共卫生
背景情况:
- Carotid-femoral脉冲波速率 (cfPWV) 是动脉硬性和心血管事件预测的黄金标准.
- cfPWV测量是耗时且昂贵的.
- 估计PWV (ePWV) 在cfPWV无法使用时提供了一个潜在的替代方案.
研究的目的:
- 调查ePWV对心血管 (CV) 和所有原因死亡率的预测价值.
- 分析ePWV在一般人群中的作用.
主要方法:
- 一项为期17年的跟踪研究,对来自克罗地亚一般人口的1086名成年人进行了跟踪研究 (EH-UH研究).
- 使用经过验证的公式计算的ePWV,包括年龄和平均血压 (MBP).
- 用于评估死亡风险的考克斯回归分析.
主要成果:
- 在随访期间发生了228例死亡.
- 与癌症死亡率相比,较高的ePWV三位数显示心血管死亡率增加.
- 每增加1m/s的ePWV与心血管死亡风险上升14%相关.
- 在CV风险较高的受试者中,ePWV显著预测了CV死亡 (HR 3.03).
结论:
- 在高CV风险人群中,ePWV是心血管死亡率的重要和独立预测指标.
- ePWV是评估心血管风险和死亡率的宝贵工具.
- 这项研究支持ePWV作为动脉硬性评估的实用替代方案.
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