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与肠道感染相关的反应性关节炎:系统性审查和元分析
Darya Shafiee1, Zhandos Salpynov1, Arnur Gusmanov1
1Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana 020000, Kazakhstan.
Journal of clinical medicine
|June 27, 2024
概括
反应性关节炎 (ReA) 可能在感染了沙门氏菌和Yersinia等常见细菌后发展. 这次系统性审查发现,在这些感染后,REA病例的比例很高,尽管由于研究异质性,研究结果需要谨慎解释.
科学领域:
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 反应性关节炎 (ReA) 是某些细菌感染后的一个已知的并发症.
- 在特定的肠道细菌感染后估计ReA的发病率对于公共卫生和临床管理至关重要.
- 之前的研究报告了感染后不同比例的REA发育,需要进行全面的合成.
研究的目的:
- 系统地审查和分析发生反应性关节炎 (ReA) 患者的比例,这些患者在感染了Campylobacter,Escherichia,Salmonella,Shigella或Yersinia.
- 量化与每个特定细菌病原体相关的ReA风险.
- 探索报告的REA发病率中异质性的潜在来源.
主要方法:
- 从Embase,PubMed,Scopus和Web of Science中对2024年1月之前发表的英语文章进行系统审查.
- 包括观察性研究报告ReA发生在患有Campylobacter,Escherichia,Salmonella,Shigella或Yersinia感染的患者.
- 随机效应元分析与异质性评估,使用I2统计和元回归来研究研究水平变量.
主要成果:
- 总共有87项研究被纳入分析.
- 在ReA发展的比例是:Campylobacter (3%),Escherichia (1%),沙门氏菌 (4%),Shigella (1%) 和Yersinia (5%).
- 在所有病原体组中观察到实质性的异质性 (I2 > 90%),表明研究结果的显著变化.
结论:
- 大部分由沙门氏菌,西格拉菌和耶尔西尼亚菌引起的感染会导致反应性关节炎.
- 这些发现强调了认识到ReA作为这些常见胃肠道感染的潜在后果的重要性.
- 在解释这些比例时建议谨慎,因为包括的研究中存在显著的异质性.
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