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在患有脑转移的患者中停止缓解性脑放射治疗:一个案例对照研究
Paul Windisch1, Jamie Lütscher1, Robert Förster1,2
1Department of Radiation Oncology, Cantonal Hospital Winterthur, 8400 Winterthur, Switzerland.
Journal of clinical medicine
|June 27, 2024
概括
7.5%的患者因脑转移而停止放射治疗,主要是由于临床状况恶化. 诸如表现不佳状态和晚期疾病等因素预测了癌症患者更高的停药率.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 临床研究 临床研究
背景情况:
- 停止放射治疗的研究不足.
- 大脑转移治疗停止缺乏详细的分析.
- 了解停止治疗对于患者护理至关重要.
研究的目的:
- 估计大脑转移的放射治疗中止频率.
- 确定停止治疗的原因.
- 确定停止治疗的预测因素.
主要方法:
- 对468名患有大脑转移的患者进行了回顾性审查,这些患者在2010-2020年接受了治疗.
- 收集了患者的特征,并计算了递归分区分析 (RPA) 和分级预后评估 (GPA) 的得分.
- 评估RPA和GPA用于预测治疗中止.
主要成果:
- 在468次骨放射治疗中,有35例 (7.5%) 被停止治疗.
- 临床恶化是停止治疗的主要原因 (74.3%).
- 停止治疗与勒普托门病,更糟糕的ECOG状态和不受控制的额外头转移相关.
结论:
- 在7.5%的大脑转移病例中,放射治疗的中止发生,主要是由于临床恶化.
- 较差的预后,表现为表现不佳的状态和晚期疾病,与停止治疗率的增加相关.
- 递归分区分析 (RPA) 组显著预测停药,与分级预测评估 (GPA) 组不同.
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