小说-Saccharomyces cerevisiae-加载的聚乙烯基罗利/SiO2纳米纤维用于伤口包裹,使用电方法制备
Yeon Seo Cho1, Hongjun Yoon1, Sung Giu Jin1
1Department of Pharmaceutical Engineering, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan 31116, Republic of Korea.
Materials (Basel, Switzerland)
|June 27, 2024
概括
充满益生菌Saccharomyces cerevisiae的聚烯和二氧化复合纳米纤维被开发为先进的伤口包裹. 这些纳米纤维显示出保护感染和增强伤口愈合的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 电纳米纤维被用作伤口包裹,用于预防和治愈感染.
- 益生菌Saccharomyces cerevisiae (SC) 显示出有助于伤口愈合的潜力.
研究的目的:
- 开发聚烯 (PVP) /二氧化 (SD) 复合纳米纤维,用于输送Saccharomyces cerevisiae (SC).
- 为了评估SC装载的PVP/SD纳米纤维作为潜在的伤口包裹.
主要方法:
- 为PVP/SD复合纳米纤维优化电.
- 在纳米纤维中加载和封装SC.
- 物理化学和机械特性 (SEM,DSC,XRD,FTIR,抗拉强度).
- 活性物质的体外释放试验.
主要成果:
- 制造了没有珠子的纳米纤维 (平均直径624.7±99.6nm).
- SEM证实了光滑的纳米纤维具有SC突起和多孔结构.
- 物理化学评估显示,SC,PVP和SD之间没有相互作用.
- 在30分钟内观察到100%的SC释放.
结论:
- 加载SC的PVP/SD复合纳米纤维是有前途的伤口带.
- 电法适合制造这些先进的伤口带.
- 开发的纳米纤维证明了用于伤口愈合应用的SC的高效输送和释放.
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