牙周炎症和牙失明与肠道中的微生物变化有关
Angela R Kamer1, Smruti Pushalkar2, Babak Hamidi1
1Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, 345 East 24th Street, New York, NY 10010, USA.
Microorganisms
|June 27, 2024
概括
牙周病 (PerioD) 和相关的口腔细菌可能会对肠道健康产生负面影响. 这项研究发现,较高的牙周炎症显著减少了肠道中有益的短链脂肪酸 (SCFA) 生产细菌.
科学领域:
- 微生物组研究的研究.
- 口腔健康 口腔健康
- 胃肠病学 胃肠病学
背景情况:
- 牙周病 (PerioD) 是一种与口腔细菌相关的慢性炎症状况.
- 之前的研究表明,口腔细菌和肠道疾病之间存在联系.
- 牙周炎症和下膜乱症对肠道的具体影响仍然不清楚.
研究的目的:
- 为了调查牙周炎症和下膜异位症是否会导致肠道异位症.
- 为了比较老年人的肠道微生物群与低而不是高的牙周炎症.
- 评估牙周状况,下干扰和肠道微生物群组成,特别是SCFA产生细菌之间的关联.
主要方法:
- 使用牙周炎症表面积 (PISA) 来比较低和高牙周炎症的老年患者.
- 使用16S rRNA测序对便和下细菌进行分析.
- 通过LEfSe分析和回归模型,评估PISA,下腺功能障碍症和肠道功能障碍症指标之间的关联,包括SCFA产生细菌.
主要成果:
- 与PISA较低的人相比,高PISA的个体在肠道中显示出某些细菌物种 (例如Coprococcus,Clostridiales) 的丰富.
- 牙周炎症 (PISA) 与肠道SCFA产生细菌的数量减少有关 (Radj = -0.38,p = 0.03).
- 下细菌失生症与肠道SCFA产生细菌水平的降低密切相关 (Radj = -0.58,p = 0.002).
结论:
- 牙周炎症和相关的下菌群变化有助于肠道细菌失生症.
- 这些口腔疾病会对肠道中有益的SCFA产生细菌的丰富性产生负面影响.
- 研究结果表明,口腔健康状况和肠道微生物组合之间存在联系,即使在没有被诊断出肠道疾病的个体中也是如此.
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