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设计,合成和生物活性的新型含有pyrazole氧化物乙烯衍生物的pyridyl
Jie He1, Beibei Zhou1, Xinjuan Wang1
1College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China.
Molecules (Basel, Switzerland)
|June 27, 2024
概括
新型pyrazole oxime ethers对各种农业害虫具有强烈的杀虫活性. 特定化合物即使在低度下也表现出高效率,为开发新的防虫剂提供了基础.
科学领域:
- 农业化学 农业化学
- 有机化学 有机化学
- 虫害管理 虫害管理 虫害管理
背景情况:
- 皮拉氧胺是一种具有潜在生物活性的有机化合物.
- 开发新的杀虫剂对于可持续农业和害虫控制至关重要.
研究的目的:
- 合成和结构识别新型pyrazole氧化埃瑟衍生物.
- 评估这些合成化合物对关键农业害虫的杀虫性能.
主要方法:
- 合成32个pyrazole氧化乙烯的合成,包括那些具有替代的pyridine环.
- 使用光谱技术进行结构识别,例如1H NMR,13C NMR和HRMS.
- 生物测试以评估对Mythimna separata,Tetranychus cinnabarinus,Plutella xylostella,Aphis medicaginis和Nilaparvata lugens的杀虫活性. 这种生物测试是为了评估对Mythimna separata,Tetranychus cinnabarinus,Plutella xylostella,Aphis medicaginis和Nilaparvata lugens的杀虫活性. 这种生物测试是为了评估对Mythimna separata的杀虫活性.
主要成果:
- 大多数合成的化合物在500微克/毫升的剂量下表现出强大的杀虫性能,可以对抗M. separata,T. cinnabarinus,P. xylostella和A. medicaginis.
- 几种化合物在500μg/mL时显示出对尼拉帕尔瓦塔素的活性.
- 化合物8a,8c,8d,8e,8f,8g,8o,8s,8v,8x和8z在100μg/mL时实现了对A. medicaginis的100%死亡率.
- 化合物8s在20微克/毫升的剂量下对M. separata具有50%的杀虫活性.
- 化合物8a,8e,8f,8o,8v和8x在20μg/mL时显示出对A. medicaginis的抑制率>60%.
结论:
- 合成的皮拉氧胺乙烯具有显著的杀虫潜力.
- 这些发现为合理设计新的,有效的基于pyrazole oxime ethers的杀虫剂提供了基础.
- 进一步的研究可以优化这些化合物用于增强害虫防治应用.
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