阿提诺洛尔和普罗普兰诺洛尔与β-环极素的高分子相互作用 谱学表征和分析应用
Hebah Alramadhan1, Abdalla Ahmed Elbashir1,2, Ahmed O Alnajjar1
1Department of Chemistry, College of Science, King Faisal University, Al-Hofuf 31982, Al-Ahsa, Saudi Arabia.
Molecules (Basel, Switzerland)
|June 27, 2024
概括
这项研究使用光谱学研究了阿诺洛和普拉诺洛的纳入复合物与β-cyclodextrin. 为了准确地对这些β-环氧德克斯林复合体进行药学分析,开发了光谱计量方法.
科学领域:
- 制药化学 制药化学 制药化学
- 超分子化学 超分子化学
- 分析化学 分析化学
背景情况:
- 阿提诺和普拉诺是广泛使用的β-阻断剂.
- 环极素以其与各种分子形成包容复合物的能力而闻名.
- 了解这些相互作用对于药物配方和输送至关重要.
研究的目的:
- 调查阿提诺洛尔-β-环氧化和普罗普拉诺洛尔-β-环氧化含有复合物的形成和特征.
- 开发和验证用于药物配方中阿诺醇和诺醇的定量分析的光谱法.
- 为了确定形成的纳入复合体的稳定性和稳定性.
主要方法:
- 在水溶液中复合.
- 使用紫外线,光谱学,1H NMR和FTIR进行了表征.
- 使用双反向图表来确定包括常数和静电测量.
- 开发和验证用于药物定量化的光谱光计方法.
主要成果:
- 阿提诺洛尔与β-环氧德克斯 (K = 2.09 × 10^-3 μM^-1) 形成了一个1:1的纳入复合物.
- 普罗巴诺洛尔形成了1:1和1:2的纳入复合物与β-环氧德素 (K1 = 5.80 × 10^-5 μM^-1,K2 = 4.67 × 10^-8 μM^-1).
- 经过验证的光谱计法显示出良好的线性 (R2>0.99) 和低检测极限 (ATE为0.13μM,PRO为0.01μM).
结论:
- 谱学证据证实了阿提诺洛尔/普罗兰诺洛尔和β-环德克斯特林之间形成的纳入复合物.
- 优化的光谱计法适用于药物配方中阿诺洛尔和诺洛尔的准确确定.
- 这项研究提供了关于这些药物与β-cyclodextrin的复杂化行为的见解,有助于药物开发.
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