饮食含量影响了经过切除的雄性大鼠中蛋白质衍生的尿液毒素的产生
Dennis P Cladis1,2,3, Kendal M Burstad1,2, Annabel Biruete2,4,5
1Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA.
Nutrients
|June 27, 2024
概括
减少饮食摄入量可能会降低慢性病 (CKD) 患者的尿素毒素 (UT). 高饮食增加了CKD大鼠的氧硫酸 (IS) 水平,这表明了潜在的治疗策略.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 来自肠道微生物群的尿液毒素 (UT) 在慢性病 (CKD) 中积累.
- 饮食和蛋白质限制是常见的CKD治疗方法.
- 饮食中的和蛋白质衍生的UT之间的联系还没有得到充分研究.
研究的目的:
- 在CKD大鼠中探索食和血清UT之间的关系.
- 调查高和低饮食对UT水平的影响.
主要方法:
- 分析了从切除术 (Nx) 和假手术小鼠的血清样本.
- 鼠被养低 (0.1%) 或高 (1.2%) 的饮食一周.
- 使用LC-MS测量了三甲基胺氧化物 (TMAO),硫酸 (IS) 和硫酸p-cresol (pCS) 的血清水平.
主要成果:
- 与假老鼠相比,Nx老鼠的TMAO,IS和pCS水平明显高于假老鼠.
- 在Nx和假老鼠中,高饮食提高了血清IS水平,在Nx老鼠中效果更为明显.
- 饮食并没有显著影响血清TMAO或pCS水平.
结论:
- 在健康和CKD鼠标模型中,高摄入量增加了血清IS.
- 减少饮食可能有利于控制CKD中UT积累.
- 需要进一步的研究来证实这些发现在人类CKD患者中.
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