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儿童超重和循环氨基酸度变化之间的关联
Jéssica de Oliveira Campos1,2,3, Tafnes Laís Pereira Santos de Almeida Oliveira1,2, Oriane Vitalis3
1Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Academic Center of Vitória, Universidade Federal de Pernambuco, UFPE, Vitória de Santo Antão 55608-680, PE, Brazil.
Nutrients
|June 27, 2024
概括
儿童超重与氨基酸 (AA) 水平的改变有关,特别是更高的分支链氨基酸 (BCAA) 和较低的甘氨酸. 这些AA变化可能先于临床代谢条件,作为早期指标.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢健康 代谢健康
- 营养生物化学 营养生物化学
背景情况:
- 不调节的血清氨基酸 (AA) 与成人肥胖和2型糖尿病 (T2D) 有关.
- 新出现的证据表明,在青春期年龄组中存在类似的联系.
- 儿童超重症中AA变化的存在在很大程度上仍未被探索.
研究的目的:
- 为了研究正常体重和超重体重儿童的血氨基酸概况.
- 确定儿童超重是否与氨基酸度的特定变化有关.
- 探索氨基酸配置文件和临床/人类参数之间的相关性.
主要方法:
- 使用液体染色学与协同质谱学 (LC-MS/MS) 结合的有针对性的代谢学.
- 对36名儿童 (7-12岁) 血氨基酸和相关分子的分析.
- 测量临床和人类参数,包括z-BMI,脂质和血糖.
主要成果:
- 超重儿童表现出氨基酸特征的改变:分支链氨基酸 (BCAA) 的增加和甘氨酸的减少.
- z-BMI与BCAA正相关,与甘氨酸负相关,独立于年龄和性别.
- 氨基酸概况显示与脂质概况和血糖相关.
结论:
- 在超重儿童中,高BCAA和低甘氨酸的模式与z-BMI,总胆固醇和甘油三有关.
- 儿童超重时的这些氨基酸干扰可能是明显代谢功能障碍的先兆.
- 改变的氨基酸样本可以作为代谢疾病风险的早期生物标志物.
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