在腹腔营养期间补充胆的证据和前景-一篇叙述性评论
Wolfgang Bernhard1, Katrin A Böckmann1, Michaela Minarski1
1Department of Neonatology, University Children's Hospital, 72076 Tübingen, Germany.
Nutrients
|June 27, 2024
概括
胆对于生长和细胞功能至关重要. 腹腔营养 (PN) 可以导致胆缺乏,增加肝病的风险,需要将其纳入PN配方.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 儿科 儿科 儿科
背景情况:
- 胆对于胎儿和产后生长至关重要,对于膜脂和甲基捐献至关重要.
- 高胆的需求与酸丁胆的合成有关,用于胆汁,脂蛋白和斯芬戈米林的生产.
- 目前的全肠直肠营养 (TPN) 实践可能会中断胆的供应,导致缺乏和不良健康结果.
研究的目的:
- 审查胆在婴儿生长中的作用及其对TPN的影响.
- 评估有关胆缺乏导致TPN相关性肝病的证据.
- 倡导将胆纳入TPN和进一步的临床研究.
主要方法:
- 在PubMed中使用术语"胆"和"肠胃营养"进行系统的文献搜索.
- 分析了47个相关出版物,包括交叉引用.
- 讨论成人临床前,观察和随机对照试验.
主要成果:
- 胆缺乏症与急性和慢性TPN相关的肝病有关.
- 有证据表明,通过肠道给予胆是安全和有效的预防TPN相关的肝脏问题.
- 在新生儿和儿童中对肠道胆的研究很少.
结论:
- 胆对于需要TPN的婴儿至关重要,根据ASPENN的定义.
- 腹腔胆补充剂可以预防与TPN相关的肝病.
- 迫切需要TPN配方和对儿童,特别是早产婴儿的临床试验.
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