微生物群如何影响乳病以及我们可以做些什么
Mariarosaria Matera1, Stefano Guandalini2
1Pediatric Clinical Microbiomics Service, Misericordia Hospital, Via Senese 161, 58100 Grosseto, Italy.
Nutrients
|June 27, 2024
概括
病 (CeD) 涉及肠道微生物群的变化,影响了对谷蛋白的耐受性. 包括特定益生菌在内的向微生物群治疗对预防和治疗有希望.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 病 (CeD) 是一种与人类白细胞抗原 (HLA) 相关的自身免疫性疾病,由质触发.
- 质不耐受性损失在肠道粘膜中的确切机制尚不清楚.
- 肠道微生物群失生症,以保护性细菌的丧失为特征,在基因易感个体中发生CeD之前.
研究的目的:
- 审查当前关于肠道微生物群与腹腔疾病相关的失生症的知识.
- 探索潜在的预防和治疗策略,针对CeD中的微生物群失衡.
主要方法:
- 使用PubMed.gov (2010年至2024年3月) 进行了一项文献综述.
- 搜索术语包括"腹腔疾病和微生物群"",腹腔疾病和微生物群"",腹腔疾病和益生菌".
- 包括的文章类型是临床试验,元分析,评论和系统评论,共364篇论文.
主要成果:
- 在CeD患者中,肠道微生物群的定量和质量变化一直被观察到.
- 微生物群相互作用影响质免疫反应,耐受性丧失和CeD病变.
- 无质饮食不能完全恢复肠道微生物的平衡,并可能对其产生负面影响.
结论:
- 肠道功能失调在乳病的发展和进展中起着重要作用.
- 针对性微生物群治疗,如精密益生菌 (例如*B. vulgatus*菌株20220303-A2),为CeD管理提供了潜力.
- 对微生物群调节的进一步研究对于预防和抵消CeD至关重要.
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