相关实验视频
Updated: Jun 22, 2025

06:22
Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
576
胰岛素抵抗对日本心力衰竭的预后影响
Keiichiro Iwasaki1, Kazufumi Nakamura1,2, Satoshi Akagi1
1Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Nutrients
|June 27, 2024
概括
胰岛素抵抗 (IR),糖尿病的关键部分,独立预测心力衰竭 (HF) 患者更糟糕的结果. 这一发现强调了IR作为心力衰竭在不同人群中的关键预后因素.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 糖尿病 (DM) 是心力衰竭 (HF) 的重要风险和预后因素.
- 胰岛素抵抗 (IR) 是DM的核心组成部分,在广泛的HF人群中具有不清楚的预后作用.
研究的目的:
- 调查胰岛素抵抗 (IR) 与不同心力衰竭 (HF) 患者队列中的临床结果之间的关联.
- 确定恒温模型对IR的评估 (HOMA-IR) 是否对HF患者是一个独立的预后因素.
主要方法:
- 在2017年至2021年期间治疗的682名心力衰竭 (HF) 患者的回顾性分析.
- 胰岛素耐药性 (IR) 定义为HOMA-IR指数≥2.5,从禁食葡萄糖和胰岛素计算出来.
- 主要结局:综合所有死因和心力衰竭住院治疗 (HHF);中位数随访时间:16.5个月.
主要成果:
- 49.4%的患者表现出胰岛素抵抗 (IR).
- IR与主要复合结果 (HR: 1.91),全因死亡 (HR: 1.86) 和心力衰竭住院 (HHF) (HR: 1.91) 独立相关.
- 所有关联的P值为<0.01,表明统计学意义.
结论:
- 恒温模式对IR的评估 (HOMA-IR) 是广泛的心力衰竭 (HF) 患者不良结果的独立预测器.
- 识别和管理胰岛素抵抗 (IR) 可能对于改善心力衰竭 (HF) 管理的预后至关重要.
相关概念视频
Pathophysiology of Heart Failure
1.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
419
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
419
Heart Failure Drugs: Inotropic Agents
564
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
564
Heart Failure Drugs: Diuretics
362
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
362
Heart Failure Drugs: β-Blockers
336
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
336
Insulin: Dosing Regimen and Adverse Effects
165
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
165

