没有证据表明影响对维生素A补充和近视反应的遗传因素之间存在关联:孟德尔的随机化研究和元分析
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Updated: Jun 22, 2025

07:06
Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients
Published on: March 29, 2022
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Xiaotong Xu1,2,3,4, Nianen Liu5,6, Weihong Yu2,3
1Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Nutrients
|June 27, 2024
概括
这项研究发现,维生素A补充剂与近视风险之间没有直接的因果关系. 需要进一步的研究来探索维生素A对眼睛健康的潜在间接影响.
科学领域:
- 眼科医生 眼科 眼科
- 营养科学 营养科学
- 遗传学 遗传学 是一个
背景情况:
- 由于研究结果不一致,维生素A补充剂和近视之间的关联仍在争论中.
- 了解这种关系对于关于维生素A摄入量和眼睛护理的公共卫生建议至关重要.
研究的目的:
- 调查维生素A补充剂与发展近视的风险之间的潜在因果关系.
- 为了利用孟德尔的随机化和元分析来进行可靠的证据合成.
主要方法:
- 利用来自英国生物银行和FinnGen的遗传变异作为门德尔随机化 (MR) 中的工具变量.
- 采用固定效应的元分析来结合来自多个数据源的MR估计.
- 评估了维生素A补充剂对近视风险的因果关系.
主要成果:
- 对MR结果的分析显示,没有令人信服的证据表明维生素A补充剂和近视风险之间存在直接因果关系 (OR = 0.99,95% CI = 0.82-1.20).
- 虽然大多数分析都没有表明因果关系的方向,但有一项分析表明潜在的反向关联 (OR = 0.002,95% CI = 1.17 × 10^-6-3.099).
- 总的来说,没有发现直接关联的有效证据.
结论:
- 这项全面的MR研究和元分析没有在维生素A补充剂和近视之间建立直接的因果关系.
- 维生素A补充剂可能不会独立地影响近视,但其眼内过程可能在近视的发展中发挥间接作用.
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