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Updated: Jun 22, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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合成,对接和DFT研究新型希夫基硫胺类类似物作为具有抗血小板聚合活动的选择性COX-1抑制剂

Yasmine M Abdel Aziz1, Mohamed S Nafie2,3, Pierre A Hanna4

  • 1Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

Pharmaceuticals (Basel, Switzerland)
|June 27, 2024
PubMed
概括

新合成的化合物10-13显示了强大的循环氧化酶-1 (COX-1) 的选择性抑制,显示出有前途的抗血小板聚合活性. 这些化合物有效地抑制由ADP和原诱导的血小板聚合,表现优于阿司匹林.

关键词:
这就是COX-1的作用.在COX-2中,COX-2是最常见的.在 DFT 方面,它是最重要的.这里是船只基地.抗血小板聚合的抗血小板聚合.硫胺是一种硫胺.

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