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用于口服药物输送的古生物体:从连续的微流体生产到粉末配方
Ivan Vidakovic1, Karin Kornmueller1, Daniela Fiedler2
1Division of Medical Physics and Biophysics, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, 8010 Graz, Austria.
Pharmaceutics
|June 27, 2024
概括
从古物脂质中衍生出来的古生物体,显示出可口药物输送的显著稳定性. 这些稳定,粉状载体有效地保护药物,如胰岛素在恶劣的胃肠道条件.
科学领域:
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
- 药品制造 药品制造 药品制造
背景情况:
- 考古体是来自自然考古脂质的新囊状结构.
- 口服药物递送面临的挑战是由于恶劣的胃肠道条件和酶降解.
- 开发像胰岛素这样的生物药物的稳定载体对于有效的口服管理至关重要.
研究的目的:
- 评估古体的稳定性和适用性,作为载体,用于口服药物输送,特别是粉末配方.
- 评估在模拟的胃肠道条件下和加工过程中考古体的弹性.
- 在肠道细胞模型中研究古基因组粘附和药物释放动力学.
主要方法:
- 通过微流体辅助的单步方法,从Sulfolobus acidocaldarius脂质中产生了考古体.
- 模型药物 (素和胰岛素) 被封装在考古体内.
- 稳定性在模拟的肠液,酸性pH和酶条件下进行了测试.
- 使用共同培养细胞模型研究了粘附和释放.
- 考古体经过冷干燥和喷雾干燥以制备粉末.
主要成果:
- 在模拟的肠液中,古体表现出极好的稳定性,在24小时内药物释放量最小 (<5%).
- 在极其酸性pH值下和在降解酶的存在下观察到高弹性.
- 观察到对肠道细胞膜的强粘附,有助于控制药物释放.
- 胰岛素封装效率在单个步骤中达到约35%.
- 在艰难的冷干燥和喷雾干燥过程中,古生物体表现出了显著的稳定性.
结论:
- 考古体具有特殊的稳定性和弹性,使其成为口服药物输送的有希望的载体.
- 考古体的稳定干粉配方是可以实现的,为生物制剂推进固体剂量形式.
- 考古体的独特特性为口服传递胰岛素等敏感治疗剂提供了可行的策略.
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