组装了基于3D打印的pH响应性胃药物输送系统
Haoye Bei1, Pingping Zhao1, Lian Shen1
1College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Pharmaceutics
|June 27, 2024
概括
这项研究介绍了一种新的3D打印胃输送系统,使用pH响应模块化单元用于智能胃病治疗. 该系统自我调节pH值,有效地提供药物,为与酸有关的疾病提供个性化治疗.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 胃肠病学 胃肠病学
背景情况:
- 胃酸分泌在胃炎和胃等胃病中至关重要,但其复杂的调节使治疗复杂化.
- 目前实时检测和控制胃酸是具有挑战性和昂贵的.
- 响应低pH值的智能胃输送系统为个性化胃病管理提供了潜力.
研究的目的:
- 开发和评估一个3D打印的,pH响应的模块化胃输送系统,用于胃pH的自我调节和向药物输送.
- 为了证明系统对胃病的个性化治疗的能力.
- 探索3D打印在创建复杂药物输送系统中的优势.
主要方法:
- 组装模块化设备使用pH响应单元,具有50mm2的释放窗口.
- 利用向下漂浮和内部气体生产,在10分钟内进行pH自我调节.
- 用抗酸剂和酸抑制剂加载装置用于药物释放研究.
- 使用3D打印来制造具有可调节结构的多层药物输送系统.
主要成果:
- 模块化单元表现出快速的pH反应和自我调节.
- 组装后的设备表现出稳定的向下漂浮和顺序分离.
- 设备在模拟生理和病理条件下成功实现了智能pH自我调节.
- 药物装载设备提供多脉冲或延长释放抗酸剂和酸抑制剂的中和后.
结论:
- 3D打印使复杂的多层次胃药物输送系统的灵活制造成为可能.
- 开发的pH响应系统为与胃酸相关疾病的个性化治疗提供了通用和可适应的策略.
- 这项技术对于在胃中输送酸不稳定的药物特别有前途.
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