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Updated: Jun 22, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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混合铜复合物L-Citrullinato-Bipyridine和L-Citrullinato-Phenanthroline:合成,表征和潜在的抗癌活性

Diego Ramírez-Contreras1, Sergio Vázquez-Rodríguez1, Amalia García-García1,2

  • 1Centro de Química, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, 18 sur y Av. San Claudio, Col. San Manuel, Puebla 72570, Mexico.

Pharmaceutics
|June 27, 2024
PubMed
概括

这项研究合成了具有潜在抗癌性能的新型类金属复合物. 在各种癌症细胞系的体外毒性测试显示出有希望的结果,暗示了治疗应用.

关键词:
1,10-南罗林的使用情况2,2-双二二二二二二二二二二二二二二二这是一种抗癌药物.氨酸 (Citrulline) 是一种氨酸.混合铜复合物的复合物.

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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay11:14

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Phase II Reactions: Miscellaneous Conjugation Reactions01:19

Phase II Reactions: Miscellaneous Conjugation Reactions

Phase II biotransformations are detoxification mechanisms that conjugate xenobiotics with endogenous substances, neutralizing their toxicity.
A key example involves the conjugation of cyanide ions, which impair cellular respiration and alter hemoglobin into non-oxygen-carrying cyanmethemoglobin. To neutralize this threat, a sulfur atom from thiosulphate is transferred to the cyanide ion, catalyzed by the enzyme rhodanese, resulting in an inactive compound called thiocyanate. The production of...
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