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聚糖微粒的配方和评估,用于控制释放甲醇化

Aneta Stojmenovski¹, Biljana Gatarić², Sonja Vučen³

¹Centre for Biomedical Research, Faculty of Medicine, University of Banja Luka, Save Mrkalja 16, 78000 Banja Luka, Bosnia and Herzegovina.

|June 27, 2024

概括

这项研究开发了新型酸盐涂层微粒用于甲,提供了可控释放儿科剂型. 这些微粒显示出改善药物输送和患者服药的前景.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
儿科医学儿科医学

背景情况:

甲醇化物用于治疗儿科疾病,如高血压和心律失常.
目前的液体配方存在局限性:稳定性差,苦味,半衰期短,需要频繁剂量.
控制释放的固体配方,如微粒,为儿科药物输送提供了潜在的改善.

研究的目的:

使用甲酸盐和多糖合物聚合物制备甲醇化微粒.
为了实现儿童使用的药物释放的控制和延长.
评估基托桑涂层对增强微粒物特性的潜力.

主要方法:

通过使用挤出技术通过离子热制备的微粒.
物理化学表征包括捕获效率,药物负载,胀指数,尺寸,质和表面张力.
选择的配方涂上了桑涂层;通过DSC,FTIR和SEM进行进一步分析.

主要成果:

桑涂层的微粒体在体外表现出有利的释放特性.
该配方系统显示了对甲醇化水的受控和持续释放的潜力.
鉴定证实了微粒的物理化学完整性和表面变化.

结论:

酸盐涂层的酸盐基微粒为儿科普拉诺洛尔化剂剂型提供了一种有前途的新方法.
与现有的液体配方相比,开发的微粒表明药物传递特性得到了改进.
需要进一步优化才能充分实现儿科患者的治疗潜力.

关键词:

基多酸盐的使用方法基烯 (Hydroxypropyl guar gum) 是一种高酸 (guar gum) 的制剂.基烯基甲基纤维素.这些微粒是微粒.儿科人口中的儿科人口.甲醇化水化合物甲醇甲基酸盐的使用方法

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