血表面处理和应用聚乙烯醇/聚乳酸电纤维化静血膜
Xiaotian Ge1, Li Zhang1, Xuanhe Wei1
1State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China.
Polymers
|June 27, 2024
概括
这项研究使用空气等离子体修饰开发了一种改进的聚乙烯醇/聚乳酸 (PVA/PLA) 血静膜. 增强的膜显著改善血静,提供了有效控制出血的新策略.
科学领域:
- 生物材料科学 生物材料科学
- 医疗设备工程 医疗设备工程
- 表面化学 表面化学
背景情况:
- 静血材料对于控制医疗程序中的出血至关重要.
- 现有的血静止剂在有效性和应用方面存在局限性.
- 聚乙烯醇 (PVA) 和聚乳酸 (PLA) 是生物相容的聚合物,有可能用于静血应用.
研究的目的:
- 开发一个改进的PVA/PLA纤维化静脉膜,增强静脉能力.
- 研究空气等离子体修饰对PVA/PLA膜的性能和性能的影响.
- 在肝脏模型中评估修改膜的静血效果.
主要方法:
- 在PVA/PLA复合纤维膜中进行电.
- 对PLA和PVA组件的空气等离子体表面的修改.
- 表面特性 (氧化,直径,粗度) 的表征.
- 评估液体丰富能力和凝固时间.
- 使用肝脏模型进行体内静血评估.
主要成果:
- 空气等离子处理增强了PVA和PLA层之间的界面粘合.
- 在等离子治疗后观察到表面氧化,纤维直径减少和粗度增加.
- 经过等离子处理的PVA/PLA膜显示液体丰富能力增加了350%.
- 凝血时间缩短到258秒.
- 与未经处理的PVA膜相比,肝脏模型中的静血能力提高了79%,与商业原蛋白相比略有改善.
结论:
- 空气等离子体修饰有效地增强了PVA/PLA纤维膜的静血特性.
- 改进的界面粘合和表面特征有助于优越的血液静止.
- 这种修改后的PVA/PLA膜为开发先进的静血材料提供了一个有前途的新策略.
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