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甘废弃物衍生的纤维素纤维作为血静剂的潜力

Siobhan Malone¹, Ramanathan Yegappan¹, Amanda W Kijas¹

¹Australian Institute for Bioengineering and Nanotechnology, Corner College and Cooper Roads, The University of Queensland, Brisbane, QLD 4072, Australia.

|June 27, 2024

概括

甘废料可以转化为纤维素微纤维,显著增强血液凝固. 这些新型生物材料对开发先进的血静伤口包裹有很大的前景.

科学领域:

生物材料科学生物材料科学
生物医学工程生物医学工程
农业科学农业科学

背景情况:

有效的出血控制在手术和创伤护理中至关重要.
目前的静血带使用纤维素产品.
甘垃圾是未充分利用的农业废物流.

研究的目的:

研究来自甘垃圾纸的纤维素微和纳米纤维的静血潜力.
评估纤维表面电荷,功能和形态对血液凝固的影响.
为了评估这些纤维素纤维在分散溶液和干布应用中.

主要方法:

从甘垃圾纸中提取和功能化纤维素,以制造微纤维和纳米纤维.
修改以引入基,碳酸和三甲基胺功能组,从而产生不同的表面电荷.
试验室血液凝固测定,包括血吸收度测量.
用纤维素纤维对凝血级联加速的评估.

主要成果:

来自甘废物的纤维素纤维在体外显示出显著的静血潜力.
一种0.25 mg/mL的纤维素微纤维分散体表现出最高的凝固性能.
带有基基的负电荷的纤维素微纤维纤维纤维加快了67%的凝血级联.

结论:

来自甘废物的纤维素微纤维在静血性伤口愈合应用中显示出相当大的前景.
没有单一的纤维特性完全决定了凝血的启动;因素的组合是有影响的.
这项研究强调了农业废物衍生纤维素在生物医学中的多功能性.

关键词:

农业废弃物农业废弃物血液凝固凝固血液凝固控制出血控制出血血静剂是一种血静剂.纳米纤维素的纳米纤维素.

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