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突破性突破性急性艾滋病毒感染在高坚持度的暴露前预防使用者中:叙述性综述
Davide Moschese1, Samuel Lazzarin2,3, Martina Laura Colombo2,3
1I Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, 20157 Milan, Italy.
Viruses
|June 27, 2024
概括
暴露前预防 (PrEP) 可以预防艾滋病毒,但突破性感染即使在高度坚持的情况下也是可能的. 在PrEP期间迅速识别急性艾滋病毒感染对于有效管理和预防进一步传播至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 暴露前预防 (PrEP) 是一种关键的艾滋病毒预防方法.
- 急性艾滋病毒感染带来了诊断挑战,特别是在PrEP使用者中.
- 对PrEP的高度坚持并不能完全消除突破性感染的风险.
研究的目的:
- 审查PrEP使用者急性艾滋病毒感染的诊断选择.
- 描述突破性艾滋病毒感染的临床特征和症状.
- 讨论PREP管理的未来前景和挑战,包括长效配方.
主要方法:
- 发表文献的叙事审查.
- 在PubMed,Embase和Scopus数据库中进行了搜索.
- 包括随机临床试验,病例报告和观察性研究.
主要成果:
- 在PrEP期间的HIV血清转化很罕见,但即使在高度坚持的情况下,也可能发生.
- 诊断存在挑战,以识别PrEP用户的急性艾滋病毒感染.
- 长效PrEP配方引入了新的管理考虑因素.
结论:
- 在PrEP期间迅速识别突破性艾滋病毒感染至关重要.
- 需要有效的后续协议,以尽量减少被忽视的感染.
- 在PrEP的背景下管理急性艾滋病毒需要持续的警和适应.
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